Background: Most fractures of the upper and lower extremities require conservative treatment, i.e. treatment with immobilization. Patients face the challenges that follow after immobilization in different ways. Immobilizations prevent the mobility of the joints and keep the fracture fragments in a favorable position to enable optimal healing of the fracture. It has been noticed that patients often complain that the immobilizations are "difficult" for them and limit their daily duties and create difficulties when performing hygiene. Aim: Examination of the quality of life of patients during conservative treatment of fractures of the upper and lower extremities at the Clinical Hospital Center of Sister Milosrdnica in the Polyclinic of the Traumatology Clinic, Draškovićeva. To determine whether there are differences in the assessment of quality of life among respondents with fractures of the upper and lower extremities, between male and female respondents, and depending on age. Subjects and methods: A total of 123 respondents, of both sexes and all age groups, were included in the research. Subjects with fractures of the upper and lower extremities who were treated conservatively at the Clinical Hospital Center of Sister Milosrdnica in the Polyclinic of the Traumatology Clinic, Draškovićeva, were included in the research. For the purpose of data collection, the questionnaire of the World Health Organization on the quality of life - Subjective assessment of health (SF-36) was used. Results: A total of 123 subjects of both sexes and all age groups were included in the research. The quality of life of subjects with upper extremity fractures is lower compared to subjects with lower extremity fractures. A statistically significant difference was observed among female respondents who rate their quality of life as lower compared to male respondents. The quality of life in relation to the age of all factors was higher for younger respondents, while it was worse for the category of respondents who are unemployed. Conclusion: The patient's quality of life during the conservative treatment of fractures of the upper and lower extremities requires an integrated approach that includes the physical, emotional, social and psychological dimensions of care. Successful pain management, proper physiotherapy, psychological support and involvement of the key family are factors that contribute to an optimal treatment outcome. Comprehensive care allows patients to return to their normal activities faster and achieve a high quality of life after a fracture.