Introduction: The number of admissions at Clinical Hospital for Traumatology varies on a daily and monthly basis. It was observed that weather conditions (rain, ice, temperature), and the day of the week affect the number of admissions. Studies carried out in other countries have shown that admission rates increase with the temperature and during the weekend. The experience for the City of Zagreb is the opposite. More patients are admitted on workdays. Aim: The study aimed to determine if the weather conditions and day of the week affect the number of admissions, along with their significance. A better understanding of their relationships will make planning and shift optimization easier while also enabling necessary preventive actions. Method: Data were collected during one year, and the study is designed as a cohort retrospective. The data on the number of admissions (29.777) and hospitalized patients (2.418), along with the hospitalization diagnosis, were collected. The weather conditions data, including the mean daily temperature, rainfall, and precipitation type collected for the Zagreb – Grič station were provided by the Croatian Meteorological and Hydrological Service. Results: The relationship between the mean daily temperature and a number of admitted patients is statistically significant, while no link was found for the number of hospitalizations. More patients were admitted in days without the rainfall. When considering the number of hospitalized patients, there was no statistically significant relation to the rainfall. The difference between the number of admissions on workday and weekend was statistically significant. No relationship was found for the number of hospitalizations and day of the week they took place. Conclusion: Temperature significantly affects the number of emergency admissions at the Clinic. Higher temperatures are linked with a larger number of patients, while the precipitation decreases that number. On average, most of the patients were admitted on Monday, and the number decreases towards the weekend when the number of admissions is significantly lower compared to the workday. Temperature, precipitation, and day of the week do not affect the number of hospitalizations.