Introduction: The principles of providing palliative care relate to the control of pain and other symptoms in order to improve the quality of life. In care, death is not delayed or accelerated, but the patient is provided with a dignified way of dying. In palliative care hospital units is provided physical, psychological, social and spiritual support and a holistic approach has a positive effect on the present symptoms and quality of life. Aim: A study was conducted to determine relationship between hospital palliative care and quality of life and symptom control in patients. Methods: A prospective cross-sectional study was conducted at Department of Palliative Medicine and Palliative Care in Special Hospital for Pulmonary Diseases in Zagreb on 52 subjects who are in advanced stage of malignant disease. Existing symptoms and quality of life were assessed on the first day of hospitalization and after 7 days of palliative care. Scales were used: EORTC QLQ - C15 PAL (The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative), ESAS–r (Edmonton Symptom Assessment System Revised), VAS (Visual Analog Scale) and PPSv2 (Palliative Performance Scale version 2). Results: The majority of respondents are female, with an average age of 70-79 living in Zagreb. All subjects suffered from malignant diseases, most often lung tumors (36,5%) with metastases (86,5%). Assessment on the first day of hospitalization showed that the most intense symptoms (ESAS-r) were: constipation (6,88), fatigue (6,21), poor well-being (5,58), shortness of breath (5,02), drowsiness (4,31), lack of appetite (4,21) and pain (4,17). The most common symptoms (EORTC QLQ - C15 PAL) were: fatigue (62,82), pain (56,08), loss of appetite (51,28), insomnia (50,00), constipation (49,35) and poor physical functioning (14,95). After 7 days of symptomatic treatment, a decrease in the intensity of symptoms of constipation, fatigue, shortness of breath and pain was observed (p <0.05). There was no decrease in the intensity of drowsiness (p = 0.106), lack of appetite (p = 0.053) and feelings of well-being (p = 0.692). Although nausea (1,81) and anxiety (3,38) were not the most intense symptoms, statistical analysis showed a decrease in the intensity of these symptoms (p <0.05). Regarding the frequency of symptoms after 7 days of symptomatic treatment, it was noticed an improvement in general quality of life, emotional functioning and improvement on the pain scale as well as the scales of individual symptoms (p <0.05), except for dyspnoea (p = 0.142). Physical functioning did not improve compared to the assessment on the first day of hospitalization. The results of the assessments of the functional abilities of the examinees (PPSv2) on the seventh day of hospitalization (36,54) do not show changes in the functional abilities of the examinees compared to the assessment on the first day (39,04). Conclusion: The hypothesis confirmed the research that by staying in the palliative care department, better control of symptoms and thus better quality of life is achieved. The hospital palliative care provided is associated with a decrease in the intensity and frequency of symptoms and an increase in the quality of life in patients, but not with changes in their functional ability.