The aim of this paper was to examine the connection between the use of toxic optimism and coping strategies in students. A total of 262 students from the Republic of Croatia participated in the research. The research was conducted online, and the participants filled out a questionnaire on sociodemographic data, the Toxic Optimism Scale, the Coping Inventory (action, positive thinking, rational thinking, instrumental support, emotional support, release of emotions, avoidance, and denial), the International Well-Being Index and Optimism Questionnaire (unrealistic optimism for positive and negative events). Before analyzing the relationship between the constructs, the structures of the Toxic Optimism Scale and the Coping Inventory were checked, and satisfactory results were obtained. Accordingly, analyses of the connection between toxic optimism and the subscale of coping strategies were conducted, and a significant positive correlation was obtained between toxic optimism and the subscale of actions, instrumental support, and positive thinking. Higher-order coping strategies were obtained by exploratory factor analysis, and the predictive contribution of gender and toxic optimism to their explanation was analyzed by hierarchical regression analysis. The results show that women who are toxically optimistic more often use active coping, while men more often use expressive support-seeking and avoidance as stress coping strategies. The results of this research are a valuable contribution to the understanding of gender differences in the context of the use of different strategies for dealing with stress and the presence of toxic optimism in everyday functioning.