Research shows that 10 to 20% of women experience symptoms of depression in the peripartum period, but the majority do not seek help. Attitudes about seeking professional help are the most consistent predictor of the use of professional mental health support services. Public stigma and lack of knowledge are mentioned as barriers to help-seeking, while locus of control has been underinvestigated in this context. The aim of this research was to examine stigma, knowledge about peripartum depression and locus of control as determinants of attitudes about seeking psychological help in the context of peripartum depression The participants were pregnant women and mothers who have an infant up to one year of age (N=279). The participants filled out The Edinburgh Postpartum Depression Scale (EPDS), Stigma Scale for Receiving Professional Psychological Help (SSRPH), The Knowledge about Postpartum Depression Questionnaire (KPPD-Q), Rotter's I-E Scale (RI-E), The Attitudes Toward Seeking Professional Psychological Help-Short Form (ATSPPH-SF) and Sociodemographic Data Questionnaire. According to the results, greater stigma is associated with more negative attitudes toward help-seeking. Better knowledge about peripartum depression is associated with more positive attitudes, while more external locus of control is associated with more negative attitudes toward seeking professional help. Public stigma and locus of control were found to be significant predictors of attitudes, while knowledge about peripartum depression was not a significant predictor. Peripartum depression did not prove to be a moderator in the relationship between locus of control and attitudes about seeking professional psychological help. The findings of this research contribute to the understanding of predictors of attitudes about seeking professional help and can serve in the creation of practical programs aimed at help-seeking in the peripartum period.