Introduction When treating patients with traumatic brain injury, the monitoring of intracranial blood pressure is applied in order to prevent secondary brain injury caused by the uncontrolled rise of blood pressure. The aim of the research The aim of this study is to examine the case series so to determine the extent to which nursing interventions will affect the rise of intracranial blood pressure. The modified sedation and analgesia, as well as the gentle performing of certain interventions are also examined in order to check the effect of preventive actions on possible oscillations of measured blood pressure so that the potential negative outcome of brain injury treatment is avoided. Subjects and methods Six patients participate in the research. They have been hospitalized between December 2018 and May 2019 in the Intensive Care Unit in Clinical Hospital Centre “Sisters of Charity” and they all fit the criteria for being included in the study. There have been 135 measurements taken before the intervention, immediately after and 30 minutes after the certain intervention. In 31.85% of measurements patients were analgosedated by midazolam, sufentanil and in some cases by izofluran. In 21.41% of measurements continuous sufentanil analgesia was used, and in 1.48% only midazolam sedation was used. In 39.26% of measurements medications weren’t used while carrying out interventions. During statistical evaluation the group of analgosedated patients was compared to the group of patients without the analgosedation (GCS less than 5). The results Regarding most interventions, like morning care, tracheal aspiration and massage of the patient, the rise of average value of ICP is noted immediately after the intervention, but the t-test for related groups showed that the rise is not statistically significant for any intervention except for the massage with turning the patient on the side. 30 minutes after all interventions the value of blood pressure comes to the initial value and stays within the variance of 1 mmHg. Conclusion Despite the small sample on which the measurements were conducted, it is proved that most nursing interventions have caused a slight rise of ICP which isn’t statistically significant. More pronounced oscillations are noticed by the patients who are in induced coma than by the ones who are in the state of natural coma. That could possibly be avoided by stricter titration of analgosedation immediately before and during the nursing interventions.