Introduction. Proper treatment and control of hypertension includes patients’ adherence to treatment. Blood pressure readings as well as the adherence to treatment largely depend on the mental state of the patients. Aim To determine interconnection between anxiety and depression with patients’ adherence to treatment, blood pressure regulation and the blood pressure readings measured outside of the hospital Hypothesis: cooperation in the treatment of high blood pressure affects the relationship between depression and blood pressure values. Methods A study was carried out at the Polyclinic for internal medicine diagnostics and treatment – Cardiology clinic of Neuropsychiatric hospital ‘Dr. Ivan Barbot’ Popovača during February 2020. 69 patients participated in the study with diagnosis of hypertension. Blood pressure values were examined by outpatient blood pressure readings. Data were obtained from one component named ‘pressure measurement log’. Based on the pressure measurement log it was concluded that there is an achievement in the positive treatment outcomes in terms of regulated hypertension. The presence of anxiety and depression was assessed based on the achievement of critical results on the Hospital Scale of Anxiety and Depression. Results Adherence to treatment is not associated with the presence of depression and anxiety. Subjects with anxiety and depression were statistically significantly less likely to control hypertension than those with anxiety, depression, and subjects without clinically significant emotional difficulties. Statistically significant associations of depression and associated anxiety-depressive symptomatology with higher blood pressure values were found. Conclusion The presence of combined anxiety-depressive symptomatology and depression are important risk factors for failure to achieve positive outcomes in the treatment of hypertension.