Background: The education of nurses is complex, and the fact that it is the only high school in the Republic of Croatia with a duration of 5 years supports this. Classes are mostly conducted using the frontal method of teaching. In earlier research, modern teaching methods have proven to be more effective compared to frontal teaching when it comes to measuring knowledge and student satisfaction with teaching. It is not known whether collaborative learning, gamification and information and communication technologies (ICT) are more effective for these outcomes than frontal teaching. Aim: The aim of the research was to compare the effect of three teaching methods in teaching about emergency medical procedures on the knowledge and satisfaction of nursing students: frontal teaching, ICT and gamification and collaborative learning. Methods: The research was conducted in 2020 on a sample of 65 fourth grade students of the School for Nurses Vrapče, Zagreb, Republic of Croatia. In three classes, teaching was held using three methods of work: frontal teaching, collaborative learning, and gamification and ICT. Each class went through 8 hours of lectures containing knowledge of emergency medical procedures within two months. After 8 hours of lectures, all students were obliged to take the same exam and fill out a survey on satisfaction with the teaching methods. Results: Students who received intervention using gamification and ICT showed the highest level of knowledge in all three examined cognitive levels of knowledge. There was no statistically significant difference between frontal teaching and collaborative learning in knowledge results. In the survey on satisfaction with teaching, the highest level of satisfaction was expressed by students who received intervention through frontal teaching, slightly lower were students who had ICT and gamification as a method of teaching. Statistically significantly worse satisfaction results were expressed by students who had collaborative learning as a method of teaching. Conclusion: Modern approaches in student education show significantly better exam results compared to frontal teaching and collaborative learning. Gamification of the teaching process increases the engagement and satisfaction of students with teaching overall.