Introduction: Bone metastases are the third most common site of cancer metastasis, resulting in pain and other serious morbidities that can significantly affect the quality of life of patients. Approaching patients with bone metastases with advanced cancer is a complex and challenging process. Nurse assessment skills, rapid recognition of complications, and knowledge of treatment plans will help patients with bone metastases throughout the care process. Implementing interventions can have a positive effect on the outcome and prevent complications and greatly affect the quality of life of the patient. Aim: The aim of the research is to examine the awareness, knowledge and involvement of nurses and technicians in the treatment of bone metastases in different departments of KBC Sestre milosrdnice (Clinic for Oncology and Nuclear Medicine and Clinic for Surgery). Methods: A cross-sectional study was conducted using an anonymous questionnaire entitled “Bone Health Management in Cancer Patients— Nurse Research” by Lawrence Drudge-Coates and associates. To use the questionnaire, the author's permission to use the questionnaire was obtained. The questionnaire was used in similar surveys and validated for the Croatian population. It covers 32 questions about the work environment, the experience of nurses and technicians, and awareness of bone metastases and treatment options. The study included a total of 60 nurses and technicians who agreed to participate in the study. The data were collected by the researcher personally. The survey was conducted in the period from May 2021 to June 2021. The research was approved by the Ethics Committee of the KBC Sestre milosrdnice. Results: The results of this study show that the subjects of the Department of Oncology and Nuclear Medicine have greater awareness, knowledge and involvement in the treatment of bone metastases than the subjects of the Clinic of Surgery. Also, respondents with higher education do not have greater awareness, knowledge and involvement in the management of bone metastases compared to respondents with lower education. The results of previous research on this and similar topics also indicate the importance of continuous education of nurses in achieving greater awareness, knowledge and involvement in a particular area of work. Conclusion: The research shows that the education and training of nurses and technicians is crucial in developing and achieving awareness, knowledge and involvement in the treatment of bone metastases. It can be concluded that continuous education and training of nurses and technicians contribute to the prevention, timely treatment and reduction of complications of bone metastases in cancer patients.