Introduction: Epilepsy is one of the most common and probably one of the oldest known diseases in neurology. Today, about 50 million people in the world suffer from epilepsy. In the Republic of Croatia, there are about 40 thousand such patients. Due to its characteristics, it is a major medical and social problem. Another important problem is the stigmatization of people with epilepsy. The stigma that accompanies people with epilepsy is the result of prejudice and ignorance. Raising awareness and better understanding the disease, reduce the stigma and increases the quality of life of people with epilepsy. Research goal: is to examine the differences in the knowledge and attitudes of part-time and full-time students of the first and third year of the undergraduate study of Nursing at the Catholic University of Croatia in Zagreb on the stigmatization of patients with epilepsy. Methods: Part-time and full-time students of the first and third year of the undergraduate study of Nursing at the Catholic University of Croatia in Zagreb participated in the research. The research was conducted using a structured questionnaire: Croatian Epilepsy Questionnaire (CEQ)-12 (CEQ 12): Research on knowledge of diseases and attitudes about patients with epilepsy in the Republic of Croatia (RH). The survey was conducted from May 7 to July 7, 2021. The questionnaire was available online via the Google Forms web application. The results: The survey showed that there is no statistically significant difference in the knowledge and attitudes based on the year of study. There is also no statistically significant difference in stigmatization between students who have a family member with epilepsy and/or experience working with epilepsy and those who do not have a member suffering from epilepsy and have no experience working with patients with epilepsy. Conclusion: The obtained results indicate the need for education through broader means of information dissemination because knowledge is the only effective tool that will improve the understanding of the disease and reduce the stigma towards people with epilepsy.