Title: The prevalence of acne vulgaris and its impact on quality of life among students at the Catholic University of Croatia Introduction: Acne vulgaris is a chronic skin disease that most commonly occurs in adolescents, but symptoms can continue into adulthood. Apart from the physical impact on the quality of life, the disease represents a significant psychological and social burden for the patient, so acne vulgaris is one of the skin diseases with the greatest impact on reducing the quality of life. Aim: is to examine the prevalence of acne vulgaris and the impact on the quality of life of students at the Catholic University of Croatia. Methods: Respondents are full-time and part-time students of the undergraduate study of nursing at the Catholic University of Croatia, age groups from 18 to 47 years. The research was conducted using an online anonymous questionnaire, Google Forms. The questionnaire included the sociodemographic status, experiences, and quality of life of subjects with acne vulgaris. The Acne-Qol standardized questionnaire was used to assess quality of life. Results: Participants who currently have acne have a statistically significantly lower quality of life than participants who do not have acne in the domains of self-perception (U = 2105.5, Z = 7.00, p <.001), emotional roles (U = 2119.5, Z = 7.16, p <.001 ), social roles (U = 1917.5, Z = 6.02, p <.001) and acne symptoms (U = 6.85, Z = 2126.0, p <.001). All effects are strongly expressed (r> .5). The chi-square test did not find statistically significant differences in the incidence of acne throughout life, depending on whether they are full-time or part-time students (χ2 (1) = 0.028, p = .867). Conclusion: This study confirmed the impact of acne on quality of life, which requires constant research into the effectiveness of the evidence-based concept of acne treatment, which will be reflected in the best treatment guidelines in the future.