Colorectal cancer is one of the most common malignant disease both in the world and in Croatia. In addition to the physical symptoms of the disease, such as pain that limit functioning, sufferers face numerous side effects such as changes in work ability, potential isolation, increased dependence on others, negative emotional states, which reduces the patients quality of life. Objective: The aim of this study was to compare the quality of life of patients with stomas to patients with closed stomas using the World Health Organization Quality of Life (WHOQOL-Bref and PWI) questionnaire. Methods: This study included 100 patients, 50 in each group (patients with stomas and patients with closed stomas). All participants completed the WHOQOL-Bref questionnaire, which consists of 26 questions covering various aspects of quality of life and PWI questionnaire (Personal Wellbeing Indeks). The scores were analyzed using statistical techniques to determine any significant differences between the two groups. Results: The results of the study showed that patients with closed stomas had significantly higher quality of life scores in all domains of the WHOQOL-Bref questionnaire compared to patients with stomas. In particular, the patients with closed stomas had higher scores in the physical health, psychological well-being, and environmental domains. Conclusion: This study suggests that patients with closed stomas after colorectal cancer have a higher quality of life compared to patients with stomas. Further research is needed to identify ways to improve the quality of life of patients with stomas.