Introduction: Addiction to psychoactive substances endangers health and reduces the quality of life for addicts. The families of addicts also suffer, so we can state that the quality of life for the family members of addicts is reduced, and their health is at risk. Addiction to psychoactive substances is also an important public health issue. Negative attitudes towards addicts are common and are one of the reasons for delayed treatment. Nurses and technicians have certain opinions and attitudes towards addicts. Objectives: The aim of the research is to examine the attitudes of nurses and technicians towards alcohol and drug addicts with regard to the experience of working with addicts. Methods: A cross-sectional study was conducted in Zagreb at the Psychiatry Clinic Vrapče from December 2020 to February 2021. The data were collected using an anonymous questionnaire specially prepared for this research. The questionnaire also contains questions based on surveys that other researchers used in their research: Drug and Drug Problems Perception Questionnaire (DDPPQ) and The Scale of Attitudes toward Alcohol, Alcoholism and Alcoholics (EAFAAA). All participants signed an informed consent. The sample was convenient, nurses and technicians employed at the Psychiatry Clinic Vrapče participated in the research. Results: The research included 94 subjects, of whom 55 work with addicts, from the Clinic for Psychiatry Vrapče. 88% of respondents agree with the statement that addiction is disease, completely or mostly, 90.5% of them believe that addiction should be treated, 88.8% of them believe that addicts often return for treatment and 70.2% of them that addict’s relapse during treatment. 41.5% of respondents consider addicts to be responsible for their illness and the same number have a neutral attitude towards the issue. 56.4% of the respondents do not consider the treatment of addicts to be futile. 45.8% of respondents consider substitution a good choice of treatment for addicts, and 44.7% are neutral on the issue. Conclusion: Since the research proved that nurses/technicians with a higher degree of education have more positive attitudes towards addicts, more should be invested in education about the disease of addiction and how to work with addicts.