Introduction: Palliative care is an active, total care for patient whose illness doesn't respond to usual treatment procedurs. Palliative care is interdisciplinary and covers the patient, family and the community. The priority of palliative care is quality of life, not life expectancy. Research objective: To determinate and compare the level of knowledge about the basic of palliative care in 3rd and 5th grades of the School for nurses in Karlovac and School for nurses "Vinogradska" and nurses in General hospital centre "The sisters of Mercy" and nurses in General hospital in Karlovac. Respondents and methods: Descriptive cross – sectional multicenter researc was condusted from February 2018. to May 2018. in Clinical hospital centre "The sisers of Mercy"at the Surgery clinic, Head and neck surgery, Department of anesthesiology intensive medicine and pain treatment, Internal clinic, Psychiatry clinic and Neurology clinic and in General hospital in Karlovac in the Departments of surgery, internal medicine, psychiatry, neurology and infectology. The survey was also conducted at 3rd an 5th grades in School for nurses in Karlovac and "Vinogradska". Results: A significant difference was found at the levels of secondary and higher education and secondary and university degress. The difference between Clinical and General hospital is not significant. A significant difference was found between hospitals and schools and between 3rd and 5th grades. Conclusion: Nurses with higher education have better knowledge of palliative care. In secondary medical schools, knowledge of palliative care is lower than that of hospitall staff participans, and in third grades the results are lower than in fifth grades, which follows the previously found situation with regard to education. The lenght of the work path didn't affect the accuracy of the questionnaire solution.