Introduction: Exposure of healthcare professionals to body fluids in the process of performing work tasks increases the risk of infection with HIV, hepatitis B, hepatitis C and other pathogenic microorganisms. The structure of health professionals who are most often exposed to infectious diseases through stabbing incidents are: nurses and technicians, doctors, cleaners. The route of transmission of infection includes injuries with sharp objects, spraying of the patient's body fluids, and bites. Objective: The aim of this study was to examine the association between risk factors and stab incident in hospital staff. Methods: A cross-sectional study on the incidence and reporting of a stabbing incident was conducted by health professionals at the Vrapče Psychiatric Clinic with the approval of the ethics committee. The study included 90 health professionals of different levels of education and years of work experience. Respondents were introduced to the purpose of the research, and signed informed consents to participate. Results: The analysis of the research results indicates that 85% of nurses are exposed to the patient's blood in their work. The most common stabbing incident occurs with a hollow needle puncture, in 40% of nurses and technicians, and in 16.7% of cleaners. Nurses and technicians consider blood sampling in 21.6% and giving injections in 49% of cases to be the most common cause of a stabbing incident. In maids, the cause of the stabbing incident in 71.4% of cases is during cleaning. The main cause of the stabbing incident, 49% of nurses and technicians consider the unpredictable reaction of patients, while the cleaners cited inappropriate waste disposal as the cause, 50% of them. Nurses and technicians stated that in 56.9% of cases they do not report a stabbing incident, and a maid in 12.5% of cases. Of the total number of nurses and technicians who were exposed to the patient's blood, 25% stated that they were offered testing for hepatitis B, and among maids this ratio was 6.7%. The results of the study suggest an association of risk factors with the stab incident, which is confirmed by the null hypothesis of this study. Conclusion: It is necessary to educate hospital staff on compliance with standard protection measures, how to handle new technological aids, proper storage of waste and access to the patient when performing health procedures, as well as mandatory reporting of stabbing incidents.