Background: Local infiltration anesthesia is a procedure of excluding the sensation of pain in a limited part of the body during surgery in sleep-deprived patients and those patients under general anesthesia. During the operation, it is very important to monitor vital signs. Local anesthetics in combination with a vasoconstrictor can affect the patient's hemodynamic stability and affect the patient's discharge from the hospital. Aim: Comparison of cardiovascular changes after the application of Lidocaine with adrenaline and Levobupivacaine with adrenaline in nose and breast surgery under general anesthesia. Methods: A retrospective study was conducted on patients who were operated on in the Bagatin Polyclinic, 3 years ago. The patients underwent nose surgery and breast augmentation. Observed variables included: age, gender, measured blood pressure values in 4 time intervals (immediately after the application of local infiltration anesthesia, 5 minutes, 10 minutes, 20 minutes), the use of atropine, the use of ephedrine, the use of analgesia after the operative procedure (in the zero hour , after 1 hour and 3 hours after op.). Results: The study included 92 subjects who were divided into two groups according to the type of surgery and the type of local infiltration anesthesia. 44 patients who had nose surgery with general anesthesia and local infiltration anesthesia with 2% lidocaine + adrenaline, and 48 patients with breast augmentation with local infiltration anesthesia with 2% lidocaine + 0.5% levobupivacaine under general anesthesia. The mean value of systolic blood pressure in all observed measurements was higher in patients who underwent nose surgery compared to patients who underwent breast surgery with a statistically significant difference (P<0.050). Conclusion: According to the obtained results, it can be concluded that local anesthetics with a vasoconstrictor have a greater effect on the increase in the value of vital signs in areas of the body with better blood supply. The same anesthetics help in better pain control after surgery.