The Internet and social media have become part of our everyday life. An increasing number of people, particularly younger ones, use social media to create and share diverse content. One of the most popular social media among young people currently is Instagram. Previous research has looked into the importance of negative consequences of frequent use of social media as well as particular behaviors correlated to usage of social media such as social comparison, self-esteem and satisfaction with physical appearance in an individual. Having said that, the aim of this particular research was to examine the correlation between the use of Instagram in regards to self-esteem, social comparison and satisfaction with the physical appearance of girls and boys. 208 participants took part in the research, of which 111 (53.4%) were female and 97 (46.6%) were male. Participants were young adults with an active Instagram profile, between 18 and 30 years old (M = 24.00, SD = 3.09). The following measuring instruments were used in the research: questionnaire on socio demographic data, scale of intensity of use of Instagram, Rosenberg's self-esteem scale, scale of ascending and descending comparisons of physical appearance, and scale of satisfaction with physical appearance. The results of research showed that the more frequent use of Instagram, is negatively related to self-esteem with females, while there is no significant correlation when it comes to male population. With both male and female population, more frequent use of Instagram is negatively related to satisfaction with physical appearance, and positively related to upward and downward social comparison. Furthermore, when we looked into upward and downward social comparison, the research showed that there is a negative relation to self esteem with the females. When it comes to males, only downward social comparison is related to self-esteem. Additionally, downward and upward social comparison are negatively associated with satisfaction when it comes to physical appearance, while on the other hand positive association has been found between self-esteem and satisfaction with physical appearance.