A sense of coherence, defined as an individual’s ability to recognize life stressors and then effectively use coping resources to adapt to stressors and maintain health, has been shown to be a significant factor contributing to positive health outcomes. In previous research, personality traits have been shown to be a significant predictor of a sense of coherence, while coping styles have been significantly associated with. The construct of intolerance of uncertainty has never been linked to a sense of coherence, so the aim of this study was to examine the predictive contribution of personality traits, coping styles, and intolerance of uncertainty to coherence in young adults. The difference in the experience of sense of coherence depending on age was also examined in this study. A total of 765 young adults (aged 20-40) participated in the study. The following questionnaires were used: the Croatian version of the personality questionnaire IPIP-50-markers for measuring Big Five model, the abbreviated version of the Sense of coherence scale (SOC), the abbreviated version of the Coping Orientation to Problems Experienced - COPE and the abbreviated version of the Intolerance of Uncertainty Scale (IUS) . The results of hierarchical regression analysis have shown that personality traits from Big Five model are strongly contributing to the explanation of the variance of sense of coherence. In addition, coping styles and intolerance of uncertainty have managed to further explain the variance of criteria. It is shown that higher levels of emotional stability, extraversion, agreeableness, conscientiousness, more frequent use of problem-oriented coping, less frequent use of coping avoidance, and lower levels of intolerance to uncertainty significantly predict a stronger sense of coherence. Young adults aged 30 and over show a significantly stronger sense of coherence than those under 30 years of age.