Introduction: The number of aesthetic treatments is increasing day by day, both in the world and in Croatia. The application of dermal fillers for rejuvenation is one of the most common aesthetic minimally invasive procedures. Aim: The aim of the research is to determine the level of quality of life of patients and satisfaction with the decision and outcome after the application of dermal fillers. Methods: A prospective observational study was conducted at the Edumed Polyclinic with 50 included patients. The examination was performed with a questionnaire of the researcher's own development on the day of filler application, before application, and on the 2nd, 14th, and 30th day. On the day of application, patients fill in demographic data, and the questionnaire assesses satisfaction with quality of life, psychosocial function, satisfaction with decision and outcome, and questions related to side effects and early complications of dermal fillers. The answers are graded on a Likert scale from 1 to 5. Results: By comparing satisfaction with quality of life, there is a statistically significant difference. Satisfaction is most pronounced on the 30th day. There is a statistically significant difference in psychosocial functions and in satisfaction with the appearance before and after application. Recommendations to the others were at least 2 days after application. Age is statistically significantly negatively correlated with satisfaction with quality of life and psychosocial functions. Education is positively correlated with recommendations made to others and marital status. Conclusion: Patients have a statistically higher quality of life on day 14 and day 30 after dermal filler application than before application. Patients are satisfied with the decision and the outcome of the procedure. There is a statistically significant difference in satisfaction with the results, and the greatest satisfaction is on the 30th day.