Introduction: The implantation of a total hip endoprosthesis is used in treatment of the hip joint disorder. It is one of the most commonly performed surgical procedures in orthopedics. The goal is to restore lost hip function, reduce or completely eliminate pain. Various risk factors (age, body weight, sex, disease, injury, sport) are considered to be the causes leading to the implantation of a total hip endoprosthesis. Objective: The aim of this study is to test the existence of a statistical association between individual risk factors that lead to the implantation of a total hip endoprosthesis. Methods: A retrospective observational study was conducted on 100 patients who were hospitalized in the Department of Orthopedics, Clinical Hospital Sveti Duh in the period from February 28, 2020 to December 30, 2020. Data were collected from medical history and the electronic database of the Department of Orthopedics. Results: Descriptive statistics suggests that older age, overweight, and the manifestation of certain diseases are risk factors for implantation of a total hip endoprosthesis. A strong positive statistical association was found between older age and the incidence of osteoarthritis and osteoporosis in individuals with implanted a total hip endoprosthesis. No statistically significant association was found between the increased body mass index and the incidence of specific disease forms. Conclusion: Older age, overweight and manifestations of certain diseases are risk factors for implantation of a total hip endoprosthesis. Older age is a pronounced risk factor for the occurrence of hip disease.