Introduction: Depressive disorder is a serious mental disorder that deeply affects all levels of functioning, and above all the quality of life of an individual. Although the etiology of this disorder remains unclear, increasing attention is focused on the impact of psychological stress and as a factor that partially conditioned the vulnerability of each person and more often as a precipitator of depression. Despite limited expansionary models of psychological stress, significant progress has been made in clarifying the physiopathological basis of depression and treatment of depressive symptoms. Stressful life events could trigger a series of psychological and physiological changes, including activation of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system, which could be called psychological stress reactions. Objective: The aim of the study is to establish the association between depressive disorder and self-esteem as an important determinant of personality, in order to detect subpopulation of patients with depression with low or extremely low self-esteem, and the impact of stressful life events in the individual's life in order to generate or structure specific models of interventions. Methods: The study included 103 patients treated with the Institute for affective disorders of the clinic for sparrow psychiatry. Participants were recruited from an ambulatory and stationary treatment model. Participants in both sexes, aged 18 to 75 years, were successively involved. The condition for participation in the research was to get acquainted with the purpose of the research and to sign the informed consent. Results: The results obtained by the investigation show a positive correlation between life stress events and self-esteem in depressed patients. Of course, the observed correlation does not prove an explicit causal link, but further prospective type studies are needed to establish a causal relationship. Conclusion: The problem of depressive disorder is a complex public health problem. For a better understanding of the etiology of depression and the connection between stressful events of life and self-respect with the occurrence of depression, it is necessary to conduct numerous studies.