Employees started working from home more often thanks to many benefits it provides. Considering that working from home is likely to become more common in the following years, it is important to investigate the job satisfaction and productivity of employees with this type of work. Therefore, the aim of this research was to examine if there is a significant differences in job satisfaction and perceived productivity of employees regarding their place of work and to determine the contribution of autonomy, job complexity and social support to perceived productivity and job satisfaction for employees who work from home and for employees who work from the employer's workplace only, according to the demand-control-support model (Johnson & Hall, 1988). A total of 118 participants were selected from a larger sample of employed participants (42,9%) who work from home at least 2 weeks a month or at least 3 days a week, and 157 (57,1%) participants who work at the employer's workplace. The results showed that people who work from home express greater job satisfaction compared to participants who do not work from home. However, the participants do not differ significantly in terms of perceived productivity regarding their place of work. The results of the conducted hierarchical regression analyzes showed that autonomy and support from supervisors are a significant predictor of job satisfaction for both groups. The results also showed that autonomy and support from supervisors were a significant predictor of perceived productivity for people who work from home, while among employees who do not work from home, only peer support was a significant predictor. This study may provide an understanding of some of the contributors to job satisfaction and perceived productivity and highlight the importance of autonomy and social support particularly in the context of working from home.