Introduction. Pain is one of the most common symptoms encountered by patients with palliative needs, and since it affects their quality of life, it is also the most necessary to alleviate or eliminate. Malignant pain is treated multidisciplinary and includes pharmacological and non-pharmacological treatment methods. Opioids are the gold standard in drug selection. Among a certain number of medical personnel, there is a fear of the consequences of the use of opioids, which often leads to their reduced use in practice. The term opiophobia is often associated with the term thanatophobia, which also affects the work of medical staff. For the best possible treatment of pain, it is necessary to examine whether these fears exist, and to educate about them. Aims. The aim of this research work was to determine the attitudes of nurses in the Service for extended treatment and palliative care Novi Marof towards opiophobia and thanatophobia. Methods. The research conducted was of a cross-sectional type, in which an anonymous (paper-pencil) survey was used, intended exclusively for nurses of the Service for extended treatment and palliative care in Novi Marof. The survey was taken from the final thesis of the author Tena Malčić, and written approval was obtained for the use of the survey. In the first part of the survey, the sociodemographic data of the respondents was collected, and in the second part, the expression of opiophobia and thanatophobia was examined using declarative sentences to which the respondents responded according to the Likert scale. The survey was completed by 72 respondents. Based on the collected data, appropriate statistical analyzes were performed in the IBM SPSS Statistics 25 program (SPSS Inc., Chicago, IL, USA). Results. Thanatophobia is equally present in nurses (regardless of the workplace, years of service or level of education). In the case of opiophobia, there is a difference - nurses working in the Department of Palliative Care show more affirmative attitudes towards the use of opioids compared to other departments of the Service. Likewise, the attitudes of nurses with longer working life are more affirmative compared to employees with shorter working life. Conclusion. All nurses have a certain level of opiophobia and thanatophobia. Certainly by providing education and support to the medical staff, it is possible to influence a change in attitudes and thereby improve the quality of care for patients who feel pain and those who need care at the end of life.