Background: The postpartum period is a very sensitive period in a woman's life. One of the most significant public health problems affecting the health of the mother and child is postpartum depression. Aim: The aim of this research was to determine the frequency of risk factors that contribute to the development of postpartum depression. Methods: The research was conducted from November 2022 to April 2023 on a convenient sample of mothers (N=195) who have children up to 6 months of age during home visits by visiting nurses in the area of Zagreb, during a home visit or online via a Google form. The survey questionnaire for mothers was the main measuring instrument. It consisted of three parts: questions about sociodemographic data, the Edinburgh Postnatal Depression Scale and the Multidimensional Scale of Perceived Social Support. Results: Most of the respondents had a university degree, were married and exclusively breastfed their children on demand. Symptoms of postpartum depression of varying intensity were present in 43 (22.05%) participants. It was found that the frequency of postpartum depression did not differ in respect with feeding (χ2 (2) = 4.75; p>.05) and maturity of the child (χ2 (2) = .14; p>.05), in contrast to the variables lack of emotional support from the husband (χ2 (2) = 18.93; p<.05) and previous mental disabilities (χ2 (2) = 6.85; p<.05). In other words, mothers with previous mental disabilities and those who are less satisfied with their husband's support have more depressive symptoms than mothers who do not have previous mental disabilities and are more satisfied with their husband's support. Also, it was found that mothers with depressive symptoms have a lower level of support from significant others, family and friends than mothers without depressive symptoms. Conclusion: The prevalence of postpartum depression in the sample was high, and it was shown that its occurrence is influenced by the following risk factors; previous mental disabilities, dissatisfaction with emotional support from the husband, and a lower level of social support from significant others, family and friends. It is important to raise awareness of the problem of the high frequency of postpartum depression and to recognize the symptoms in time in order to take the necessary measures and provide adequate psychosocial support.