Introduction: Burnout syndrome is one of the main public health problems in the working population. It consists of emotional disorders that occur due to continuous stress at the workplace; is characterized by constant emotional exhaustion, the presence of cynicism or a distant attitude towards his workplace. Objectives: The goal of the research was to investigate the presence of burnout syndrome, and to examine the existence of differences in the occurrence of burnout syndrome between nurses employed at different workplaces in the Merkur Clinical Hospital in 2023. Methods: The research was conducted at the Merkur Clinical Hospital during April and May 2023, and the results were collected using surveys at the hospital's workplaces. The survey consisted of the "Questionnaire for the assessment of psychosocial risks at the workplace of cabin crew", the "Questionnaire of the intensity of burnout at work" and sociodemographic data. Results: There were 187 participants in the research. The majority of the participants were female, with a university degree and an average work experience of 10 years. Significant symptoms of burnout at work are shown by 40,4% of participants working in surgery departments versus 14,5% of participants working in internal medicine departments. Statistically significant differences were found on the following subscales: Disagreement and indecisiveness at work, Pressure at work, Contradictions in the performance of tasks, Concern for health related to work, Too much workload, Too little workload, Time limits/pressures, Obstacles at work where statistically significantly higher results are achieved by participants who are employed in surgery departments compared to participants who are employed in internal medicine departments (p<0.01). Conclusion: The occurrence of burnout syndrome is more common in nurses working in surgical wards than in nurses working in internal medicine wards. Creating a healthy environment can reduce the frequency of symptoms and improve the quality of medical care provided.