Previous research has found a relationship between personality traits and adaptation to college, and most studies have found that neuroticism negatively predicts all aspects of adaptation to college, while conscientiousness positively predicts academic and emotional adaptation, and extraversion predicts social adaptation. However, the pathways through which personality traits are significant predictors of adaptation to college have been insufficiently studied. This study examined the relationship between personality traits and adaptation to college with an emphasis on coping strategies and perceived social support as mediators in their relationship. The sample consisted of 305 Croatian students and the research was conducted online. The questionnaires used were the IPIP Big-Five markers (Mlačić and Goldberg, 2007), Multidimensional scale of perceived social support MSPSS (Zimet et al., 1988), ), adaptation of Coping Inventory for Stressful Situations CISS (Sorić and Proroković, 2002). and a newly constructed adaptation to college questionnaire. The results found a significant association of conscientiousness, extraversion, and emotional stability with all aspects of adaptation to college. Agreeableness significantly predicted social adaptation, and intellect significantly predicted academic adaptation, adaptation to separation from family, and institutional attachment. Coping strategies and perceived social support were also significant predictors of adaptation. Mediation analyzes found a significant mediating effect of coping strategies in relationship between personality traits and adaptation to college, while perceived social support was a significant mediator in relation between specific personality traits and social adaptation. The research offers a new look at the current knowledge about the adaptation to college, which can be difficult at the current time of the pandemic, where social contacts have been reduced and the way of studying has suddenly changed. The thesis explains the possible practical implications of the research.